Scientific References

The ingredients in Make America Slim Again are backed by peer-reviewed research and clinical studies published in respected scientific journals. Below are the references supporting our formula.

Akhbari, M., Jabbari, M., Ayati, M. H., & Namazi, N. (2021). The effects of oral consumption of honey on key metabolic profiles in adult patients with type 2 diabetes mellitus and nondiabetic individuals: A systematic review of clinical trials. Evidence-Based Complementary and Alternative Medicine, 2021(1), 1-12. https://doi.org/10.1155/2021/6666832

Ali, A. M., & Kunugi, H. (2020). Royal jelly as an intelligent anti-aging agent—a focus on cognitive aging and alzheimer's disease. Antioxidants, 9(10), 937. https://doi.org/10.3390/antiox9100937

Asbaghi, O., Ghanbari, N., shekari, M., Reiner, Z., Amirani, E., Hallajzadeh, J., Mirsafael, L., & Asemi, Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN, 38, 43-49. https://doi.org/10.1016/j.clnesp.2020.04.010

Bakour, M., Laaroussi, H., Qusaidi, D., El Ghouizi, A., El-Safi, N., Mechchate, H., & Lyoussi, B. (2022). Bee bread as a promising source of bioactive molecules and functional properties: An up-to-date review. Antibiotics, 11(2), 203. https://doi.org/10.3390/antibiotics11020203

Duru, K. C., Mukhlynina, E. A., Moroz, Gleb. A., Gette, I. F., Danilova, I. G., & Kovaleva, E. G. (2020). Anti-diabetic effect of isoflavone rich kudzu root extract in experimentally induced diabetic rats. Journal of Functional Foods, 68, 103922. https://doi.org/10.1016/j.jff.2020.103922

Jiang, D., Wang, D., Zhuang, X., Wang, Z., Ni, Y., Chen, S., & Sun, F. (2016). Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway. Lipids in Health and Disease, 15(1), 214. https://doi.org/10.1186/s12944-016-0383-4

Kamiya, T., Takano, A., Matsuzuka, Y., Kusaba, N., Ikeguchi, M., Takagaki, K., & Kondo, K. (2012). Consumption of Pueraria Flower extract reduces body mass index via a decrease in the visceral fat area in obese humans. Bioscience, Biotechnology, and Biochemistry, 76(8), 1511-1517. https://doi.org/10.1271/bbb.120235

Kunugi, H., & Ali, A. M. (2019). Royal jelly and its components promote healthy aging and longevity: From animal models to humans. International Journal of Molecular Sciences, 20(19), 4662. https://doi.org/10.3390/ijms20194662

Lee, C. M., Yoon, M. S., & Kim, Y. C. (2015). Effects of pueraria lobata root ethanol extract on adipogenesis and lipogenesis during differentiation into adipocytes. Toxicological Research, 31(2), 191-201. https://doi.org/10.5487/tr.2015.31.2.191

Morita, H., Ikeda, T., Kajita, K., Fujioka, K., Mori, I., Okada, H., Uno, Y., & Ishizuka, T. (2012). Effect of royal jelly ingestion for six months on healthy volunteers. Nutrition Journal, 11(1), 77. https://doi.org/10.1186/1475-2891-11-77

Petelin, A., Kenig, S., Kopinč, R., Deželak, M., Černelič Bizjak, M., & Jenko Pražnikar, Z. (2019). Effects of royal jelly administration on lipid profile, satiety, inflammation, and antioxidant capacity in asymptomatic overweight adults. Evidence-Based Complementary and Alternative Medicine, 2019, 1-11. https://doi.org/10.1155/2019/4969720

Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., & Mobasseri, M. (2012). Effects of royal jelly supplementation on body weight and dietary intake in type 2 diabetic females. Health Promotion Perspectives, 2(2), 231-235. https://doi.org/10.5681/hpp.2012.028

Ugusman, A., Shahrin, S. A. S., Azizan, N. H., Pillai, S. B., Krishnan, K., Salamt, N., Aminuddin, A., Hamid, A. A., Kumar, J., & Mokhtar, M. H. (2022). Role of honey in obesity management: A systematic review. Frontiers in Nutrition, 9, 924097. https://doi.org/10.3389/fnut.2022.924097

Yang, J., Yin, J., Gao, H., Xu, L., Wang, Y., Xu, L., & Li, M. (2012). Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evidence-Based Complementary and Alternative Medicine, 2012, 363845. https://doi.org/10.1155/2012/363845

Yang, Y., Lu, R., Gao, F., Zhang, J., & Liu, F. (2020). Berberine induces lipolysis in porcine adipocytes by activating the AMP-activated protein kinase pathway. Molecular Medicine Reports, 21, 2603-2614. https://doi.org/10.3892/mmr.2020.11070

Yates, B. (n.d.). Holy Basil: An overview of the research and clinical applications. Retrieved September 25, 2025

Zheng, G., Lin, L., Zhong, S., Zhang, Q., & Li, D. (2015). Effects of puearin on lipid accumulation and metabolism in high-fat diet-fed mice. PloS One, 10(3), e0122925. https://doi.org/10.1371/journal.pone.0122925

Zulkifli, S. N. I., Hamad, I. F. M., Saludes, J. P., Dalissay, D. S., & Ismail, W. I. W. (2022). Potential of natural honey in controlling obesity and its related complications. Journal of Evidence-Based Integrative Medicine, 27(1), 2515690X221033. https://doi.org/10.1177/2515690x22110330